Enfrente: opposite a place

Enfrente locates something facing or opposite another place.

The idea

Use enfrente alone when the reference is understood and enfrente de before a noun.

La farmacia está enfrente del hospital.The pharmacy is opposite the hospital.
Ana espera enfrente de la biblioteca.Ana waits opposite the library.
Hay una tienda enfrente de mi casa.There is a shop opposite my home.
El parque está enfrente, al otro lado de la calle.The park is opposite, on the other side of the street.
Vivimos en el edificio de enfrente.We live in the building opposite.
¿Está la parada enfrente del mercado?Is the stop opposite the market?

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Enfrente expresses facing position; it does not require a street between the places.

Choose the preposition before the noun: Ana espera enfrente ___ la biblioteca. (de / con)
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de
Enfrente de introduces the library as the reference.
Choose the contraction of de + el: La farmacia está enfrente ___ hospital. (del / al)
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del
De + el contracts to del before hospital.
Choose the word matching the location: La tienda está al otro lado de la calle, directamente frente a mi casa: está ___. (enfrente / detrás)
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enfrente
Directly opposite the house fits enfrente.

Describe a shop opposite your home and ask about a stop.